The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several units that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.

Unit of Clinical Epidemiology (KEP)
Research at MedS and KEP combines clinical, epidemiological, and computational expertise with the aim to improve the understanding and treatment of a broad range of medical conditions. We focused on translational research studies to improve prediction of disease onset, treatment effects, and disease outcomes.

We are seeking a bioinformatician/computational biologist to support large-scale genetic, metagenomic and other “omics”-type of research in the field of gastrointestinal (GI) disease (PI Mauro D’Amato, http://ki.se/en/people/maudam), with focus on the genetic causes of inflammatory bowel disease (IBD), irritable bowel syndrome (IBS, also see www.bellygenes.org) and other GI conditions.

Duties
The successful candidate will be responsible for the analysis of high-throughput  molecular data (primarily genetic, but also epigenetic, transcriptomic, metagenomic etc) coming from large cohorts of GI disease patients. He/she will also be responsible for the reporting of project results to colleagues within the international collaborative network, and at international meetings.

The position, which is based at a new GI research team at the Center for Molecular Medicine  is available immediately for 2 years, with the possibility for extension 

Entry requirements

  • PhD in computer science, bioinformatics, biostatistics, genetics, biology or related field with experience in analysis of large datasets.
  • Experienced user of R/Bioconductor, Python and programming languages. Unix environments and high-performance computing clusters.
  • Demonstrated knowledge of bioinformatic and computational approaches to the study of human genetics and “omics”, and good understanding of “biology” (biological questions)
  • Demonstrated experience in handling large datasets (primarily GWAS), and/or to work with different type of genetic, epigenetic (DNA methylation, miRNA), transcriptomic and metagenomic data, 
  • Good knowledge of data integration, multivariate analyses, meta-analyses
  • Additional background in statistics, machine learning and/or predictive analytics is a plus
  • Team-work attitude, impeccable organizational skills, and previous participation in international research activities/projects/publications
  • Excellent spoken and written English.

A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances.

Application process

  • An employment application must contain the following documents in English
  • A letter of interest, also outlining how the candidate’s experience and background fulfills the specific duties and entry requirements.
  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

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