ESNM Newsletter - October 2019


for making the NeuroGASTRO 2019, such an outstanding event! Click here to watch a short review on our
neurogastroenterology and motility congress!

Happy Anniversary Paul Enck
I would like to highlight some of the milestones of Prof. Enck’s remarkable career. His main interests and focus in research are the brain-gut-axis in health and disease with focus on functional gastrointestinal disorders, gut microbiota, regulation of eating and food intake, the pathophysiology of nausea, vomiting and motion sickness, and the psychophysiology and neurobiology of the placebo response, with specific emphasis on age and gender contributions. He has published more than 180 original data paper in scientific, peer-reviewed journals, several book chapters and review articles. His seminal papers evaluating the role of the brain-gut-axis in functional bowel disorders are a tour de force in translational research. His work has continued to be highly cited and helped to advance the field not only of neurogastroenterology and motility or gastroenterology, but medicine at large. 

G. Barbara, President ESNM

Congratulation to Vincenzo Stanghellini

We are very delighted to hand out the ESNM Lifetime Achievement Award to Vincenzo Stanghellini!

Congratulation to all Award Winners during the NeuroGASTRO in Lisbon!

We are very pleased to congratulate all Award Winners: Javier  Aguilera-Lizarraga, Rubina Aktar, Maria Julieta Arguero, Lisse Decraecker, Magdy El-Salhy, Nikita Hanning, Jasper Pannemans, Mafalda Sousa, Nathalie Stakenborg and Lucas Wauters

Congratulation Jan Tack

We are very happy to announce that Jan Tack, long-time member of the ESNM Steering Committee, has been elected President of the Rome Foundation. Congratulation! The Rome Foundation is an independent not for profit organization that provides support for activities designed to create scientific data and educational information to assist in the diagnosis and treatment of functional gastrointestinal disorders (FGIDs). Our mission is to improve the lives of people with functional GI disorders.

Congratulation Niall Hyland

Niall Hyland, member of the ESNM Steering Committee has been awarded a significant global grant to advance insight into how our gut bacteria responds to affects medications for depression and anxiety. Niall Hyland at APC Microbiome Ireland SFI Research Centre, University College Cork was awarded the  EUR 100,000 global grant by Nature Research and Yakult, beating a field of nearly 200 international applicants.

A New Approach for PPI Refractory Gastroesophageal Reflux Disease Case: A Novel Gastric-Retentive Bile Acid Sequestrant

Last year an interesting Phase 2b study presented in DDW about a novel gastric-retentive Bile Acid Sequestrant (IW-3718). This year in DDW secondary end-points were presented. This drug is a slow-release tablet of colesevelam. This drug binds to bile acids which are refluxed into the stomach. Different doses of IW-3718 (500-1000-1500 mg) were given QD for 8 weeks and compared to placebo. All patients continued with PPI. Severity and frequency of GERD symptoms were improved especially with 1500 mg dose. Adverse event rates were 42-52% for IW-3718 and 41% for placebo. 10 patients were withdrawn because of adverse events; 1.4-4.4% for IW-3718 and 4.3% for placebo.
Authors concluded that IW-3718 was efficacious in reducing of symptoms in PPI refractory GERD patients. IW-3718 was safe and well-tolerated at all doses.


Future Research Demands of the United European Gastroenterology (UEG) and its Members Societies

The Research Committee of the United European Gastroenterology (UEG) federation decided more than a year ago (Spring 2018) to conduct a survey among its 17 member societies about their demands for future research topic and areas. This survey was conducted over the summer of 2018, and the results are now presented in a paper published in the UEG Journal, with first author Paul Enck, representing ESNM in the UEG Research Committee. Take a look and see what all UEG member societies have in common when it comes to research ...


Best Abstracts at NeuroGASTRO 2019!

Congratulation to Javier Aguilera from Leuven, winning the best abstract in basic science, "Psychological Stress Triggers A Bystander Immune Response To Food Antigens Leading To Neuronal Hyperexcitability And Visceral Hypersensitivity"!

The abstract reads: In patients with Irritable Bowel Syndrome (IBS), psychological factors are associated with increased postprandial symptoms, albeit the underlying mechanisms remain unclear. In this study, we showed in mice that psychological stress can impair the establishment of oral tolerance to dietary antigens and lead to mast cell-induced visceral hypersensitivity upon antigen ingestion. This findings suggest that stress may play an important role in the mechanism of food-induced abdominal pain in IBS. Abstract 60

Congratulation to Lisse Decraecker winning the best abstract in translational science, "Activity-Based Profiling Of Secreted Peptidases In Irritable Bowel Syndrome".
The abstract reads:We investigated the serine peptidase activity in biopsy supernatants of IBS patients and healthy volunteers (HV) and showed an increase in trypsin-like, but not in chymotrypsin-like or elastase-like activity in a subgroup of IBS patients (1). This increase in trypsin-like activity was significantly inhibited by the protease-inhibitor UAMC-00050 (2), which has demonstrated efficacy in pre-clinical models of IBS. Therefore, our results add further support to the translational potential of UAMC-00050 to treat IBS. Additionally, by using this inhibitor as a scaffold, we will develop novel activity-based probes to identify the proteases underlying this increased proteolytic activity in IBS Abstract 49

Congratulation to Magdy El-Salhy winning the best abstract in clinical science, "Faecal Microbiota Transplantation (FMT) in IBS using a super-donor: A randomised, double-blind placebo-controlled study".

The abstract reads: A large, randomised, double-blind, placebo-controlled study have shown that faecal microbiota transplantation (FMT) using a single ‘super-donor’ is an effective and well tolerated treatment for irritable bowel syndrome (IBS), producing high rates of clinical response and marked symptom improvements.1 The study highlighted the importance of donor selection for optimising the effectiveness of FMT as a treatment for IBS. Abstract 89

2019 2nd Neurogastro Day Switzerland
On Saturday, August 24th 2019, more than 70 medical professionals (gastroenterologists, dieticians, surgeons and nutrition specialists) from all over Switzerland and abroad participated in the second SwissNGM Neurogastro Day, organized by PD Dr. Pohl, Treasurer SwissNGM, and supported by Lasermed, Permamed and Takeda. A rich and interesting program combining lectures, case studies, tandem sessions and State of the Art talks was presented to the audience. Internationally renowned expert Prof. Witt talked about complementary medicine in functional gastrointestinal disorders.


With the aim to build successful collaborations, reinforcing the cross-talk between clinical and basic research, the 3rd nEUROgastro TANDEM meeting succeeded also this year to create a European network of young investigators, eager to bring together a new set of valuable expertise to discover new knowledge in the Neurogastroenterology field. Announced by the respective National NeuroGASTRO Societies, GENIEUR network and ESNM, the nEUROgastro TANDEM meeting 2019 was held at the Chronic Diseases Research Center (CEDOC) / NOVA Medical School, NOVA University of Lisbon, Portugal, from September 2 to 4.

1st German Australian Psycho-Neuro-Gastroenterology Summer School

The 1st Tübingen based German Australian Psycho-Neuro-Gastroenterology Summer School is a collaborative initiative between Tübingen University and the Universities of Newcastle and Brisbane, Australia. Those insitutes are already closely connected. In the past, a research axis leading from Tübingen to Newcastle and Brisbane has been developed with a focus on psychoneurogastroenterology. This is an emerging research and clinical field in-between the disciplines of psychology/psychosomatic/psychiatry, neurology/neurosciences and gastroenterolog. The field has no established curriculum in current medical teaching and training. It is facing increasing demand and attention from patients, doctors, and the public, as it covers a wide range of patients in need for adequate diagnosis and therapy.

Upcoming ESNM Educational and Endorsed Events

IX Curso de Neurogastroenterología para Residentes
Neurgastroenterology Course for trainees organised by the Spanish Digestive Motility Group
November 21 - 22, 2019Location: Hotel Barceló Sants, Barcelona, Spain

XXVII Reunión Anual del GEMD 2019
Annual meeting of the Spanish Digestive Motility Group
November 22 - 23, 2019, Location: Hotel Barceló Sants, Barcelona, Spain

2. Conference Probiotics in Digestive Medicine

Organised by the Croatian Gastroenterology Society- section for functional bowel diseases HUNM
November 22 - 24, 2019, Location: Hotel Plaza Histria, Pula, Croatia

Ascona III Meeting, Advances in Clinical Measurement  Gastrointestinal Motility & Function
Organised by the International Working Group for Disorders of Gastrointestinal Motility & Function

July 12-17, 2020, Location Centro Stefano Franscini,  Monté Verita, Ascona, Switzerland

UEG Week October 19-23, 2019, Barcelona, Spain

UEG Week Pathways: See at one glance which sessions are most relevant for you!

Overwhelmed by the choice the UEG Week Scientific Programme offers? The UEG Week Pathways help you navigate through this huge choice, searching the online scientific programme by topic.UEG Week Pathways

Women in GI -  Making equality a reality
For the first time, we will offer a special women networking event at UEG Week Barcelona 2019. The network is dedicated to enable female gastroenterology and surgical trainees, junior scientists and other GI health care professionals to communicate with their peers and seniors to network, explore professional opportunities and establish contacts for future collaborations. Make sure to use and follow #UEGWomeninGI on social media in order to connect with your peers and get latest information.

Save the date for the
GMFH Wold Summit 2020, March 7-9, Madrid, Spain

Join the European Society of Neurogastroenterology and Motility (ESNM) and the American Gastroenterological Association (AGA)  for the 9th annual Gut Microbiota for Health (GMFH) World Summit. This preeminent meeting on the gut microbiota will take place March 7 & 8, 2020 in Madrid, Spain.

Abstract Deadline FNM 2020 is Approaching

Hand in your abstract for the FNM 2020 Meeting, March 25-28, 2020 Adelaide, Australia.

Submission deadline November 7, 2019! Click here to submit your abstract!
Detailed programme online!
Register now, to receive the early bird fee! Click here for registration

ESNM Young Investigator Award to attend the FNM 2020

ESNM will support 3 Young Investigators (ESNM Members) to attend the FNM 2020, March 25-28, in Adelaide Australia with a grant of EUR 750,-

Don't miss to submit your abstract to the FNM Meeting on one of the following topic: Mechanisms Underlying Normal and Disordered GI Function, Pain Mechanisms and Visceral Hypersensitivity, Pathophysiological and Clinical Aspects of Functional Esophagogastro-Intestinal Disorders, Physiological Control of Upper GI Functions, Including Relevance to Appetite Regulation, Role of Microbiome and Diet in GI Function, Technologies for the Assessment of Esophagogastrointestinal Motility and Perception and Therapies for Disordered Gut Function and Functional GI Disorders.
Submission deadline November 7, 2019!


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