Call Scientific Committee Representative UEG
We are looking for a ESNM representative in the UEG Scientific Committee (SciComm). The Committee is responsible for delivering the annual programme of UEG Week and thereby disseminating world leading research on digestive health. Its goal is to organise the best international multidisciplinary digestive health meeting in the world by sharing the highest quality research and best clinical practice, delivering most up-to-date education, and bringing together the sharpest minds. We are looking forward receiving your application including a short CV including and motivation letter! Please submit application via email to info@esnm.eu until Wednesday October 14, 2020.

Organisation of the GI Motility and Functional Disorders Unit, Nazareth Hospital, Israel
The Organisation of the GI Motility and Functional Disorders Unit, Nazareth Hospital, Israel is introducing itself. Watch the video on our YouTube channel!

Clinic of Internal Diseases Propaedeutic, Gastroenterology and Hepatology Sechenov University Russia
Clinic of Internal Diseases Propaedeutic, Gastroenterology and Hepatology (head of department – Prof. Vladimir Ivashkin), one of the oldest in Sechenov University, was founded in 1874, and since then close attention has been paid to the gastrointestinal motility. Under the guidance of the leading gastroenterologists of the Soviet Union and later the Russian Federation the motility of the esophagus, stomach and colon was studied on a polygraph, and the conventional manometry was performed as well.

Graphical Abstract: Personalized Mapping of Drug Metabolism by the Human Gut Microbiome

Individual differences in response to the same drug are very common in clinical practice. Doctors are to often simplifying this problem and use the fact that not all the people are the same and that there are genetic variations responsible for side effects as the universal response to this question. In the meantime, our patients suffer from the side effects, or, maybe even worse, from lower efficacy of the drug that is indispensable for their condition. Click on the link to read full article

DOI: doi.org/10.1016/j.cell.2020.05.001

Review: The use of Impedance Planimetry (Endoscopic Functional Lumen Imaging Probe, EndoFLIP®) in the Gastrointestinal Tract: A Systematic Review

This systematic review summarizes the available data in literature until June 2020, using MEDLINE‐PubMed, Cochrane Library, and Google Scholar databases on the use of the EndoFLIP® system in the gastrointestinal tract, including sphincteric and non‐sphincteric regions. EndoFLIP® has a promising role in the diagnosis of the major motility disorders, but the use of EndoFLIP® in other esophageal diseases like GERD, eosinophilic esophagitis or in other sphincter regions (anal canal, pylorus) will need further studies for confirmation. Click on the link to read full article DOI: doi.org/10.1111/nmo.13980

Clinical Review: ESNM-ANMS Review. Diagnosis and Management of Globus Sensation: A Clinical Challenge

Globus is a chronic functional disorder of the upper aerodigestive system which continues to represent a clinical challenge. A diagnosis of idiopathic globus requires exclusion of pharyngeal, laryngeal, and esophageal disorders with laryngoscopy, endoscopy, high‐resolution manometry, barium radiography, and/or ambulatory reflux monitoring. When identified, secondary etiologic factors are targeted for specific management like reassurance, neuromodulators or complementary therapy. Click on the link to read full article
https://doi.org/10.1111/nmo.13850

Clinical Guideline: ACG Clinical Guidelines: Diagnosis and Management of Achalasia

ACG published in American Journal of Gastroenterology the most recent clinical guideline regarding the diagnosis and the management of achalasia. Click on the link to read full article
DOI: doi.org/10.14309/ajg.0000000000000731

Graphical Abstract: Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity Following Inflammation

A recent paper in Cell Reports shows that enteric glia regulate macrophage activation and visceral sensitivity following intestinal inflammation through mechanisms that require glial connexin-43 (Cx43) and macrophage colony-stimulating factor (M-CSF) production. Inflammation-induced glial M-CSF production is regulated by Cx43, protein kinase C (PKC), and tumor necrosis factor (TNF)-alpha converting enzyme (TACE).

Click on the link to read full article DOI: https://doi.org/10.1016/j.celrep.2020.108100